Article
A Common Variant at the 14q32 Endometrial Cancer Risk Locus Activates AKT1 through YY1 Binding.
American journal of human genetics - 2 Jun 2016
Painter Jodie N, Kaufmann Susanne, O'Mara Tracy A, Hillman Kristine M, Sivakumaran Haran, Darabi Hatef, Cheng Timothy H T, Pearson John, Kazakoff Stephen, Waddell Nicola, Hoivik Erling A, Goode Ellen L, Scott Rodney J, Tomlinson Ian, Dunning Alison M, Easton Douglas F, French Juliet D, Salvesen Helga B, Pollock Pamela M, Thompson Deborah J, Spurdle Amanda B, Edwards Stacey L
Abstract excerpt
A recent meta-analysis of multiple genome-wide association and follow-up endometrial cancer case-control datasets identified a novel genetic risk locus for this disease at chromosome 14q32.33. To prioritize the functional SNP(s) and target gene(s) at this locus, we employed an in silico fine-mapping approach using genotyped and imputed SNP data for 6,608 endometrial cancer cases and 37,925 controls of European...
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