Article

Programmed downregulation of METTL3 is essential for decidualization in both humans and mice

2025-06-18

Abstract excerpt

N 6 -methyladenosine (m 6 A), the most abundant mRNA modification in eukaryotes, plays an essential role in regulating gene expression. Our prior research, alongside that of others, demonstrated that conditional uterine knockout of methyltransferase-like 3 (METTL3), the enzyme responsible for m 6 A modification, led to complete failure of embryo implantation and decidualization. Intriguingly, METTL3 expression i...

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Literature Corpus work: e75e7b11-459a-5ec5-b42f-001b2f1b3a00
DOI: 10.1101/2025.06.14.659666

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