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Article

Cross-cleavage activity of Cas6b in crRNA processing of two different CRISPR-Cas systems in Methanosarcina mazei Gö1.

RNA biology - 1 Apr 2019

Nickel Lisa, Ulbricht Andrea, Alkhnbashi Omer S, Förstner Konrad U, Cassidy Liam, Weidenbach Katrin, Backofen Rolf, Schmitz Ruth A

Abstract excerpt

The clustered regularly interspaced short palindromic repeat (CRISPR) system is a prokaryotic adaptive defense system against foreign nucleic acids. In the methanoarchaeon Methanosarcina mazei Gö1, two types of CRISPR-Cas systems are present (type I-B and type III-C). Both loci encode a Cas6 endonuclease, Cas6b-IB and Cas6b-IIIC, typically responsible for maturation of functional short CRISPR RNAs (crRNAs). To...

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Identifiers

PMID: 30153081
DOI: 10.1080/15476286.2018.1514234
PMCID: PMC6546354

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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