Article
Cmr1 enables efficient RNA and DNA interference of a III-B CRISPR-Cas system by binding to target RNA and crRNA.
Nucleic acids research - 2 Nov 2017
Li Yingjun, Zhang Yan, Lin Jinzhong, Pan Saifu, Han Wenyuan, Peng Nan, Liang Yun Xiang, She Qunxin
Abstract excerpt
CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated) systems provide adaptive immunity against invasive nucleic acids guided by CRISPR RNAs (crRNAs) in archaea and bacteria. Type III CRISPR-Cas effector complexes show RNA cleavage and RNA-activated DNA cleavage activity, representing the only known system of dual nucleic acid interference. Here, we investigated the function of...
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