Article
Alpha 6 beta 4 integrin and newly deposited laminin-1 and laminin-5 form the adhesion mechanism of gastric carcinoma. Continuous expression of laminins but not that of collagen VII is preserved in invasive parts of the carcinomas: implications for acquisition of the invading phenotype.
The American journal of pathology - 1 Sept 1996
Tani T, Karttunen T, Kiviluoto T, Kivilaakso E, Burgeson R E, Sipponen P, Virtanen I
Abstract excerpt
We studied the expression and distribution of different laminin chains, the alpha 6 beta 4 integrin and type VII collagen, i.e., components of the epithelial adhesion complex, in gastric carcinomas and in suggested preneoplastic stages of this malignancy. Intestinal-type gastric carcinomas showed...
Topics
- Antigens, Surface
- Biomarkers, Tumor
- Cell Adhesion
- Cell Adhesion Molecules
- Collagen
- Epithelium
- Gastritis, Atrophic
- Humans
- Integrin alpha6beta4
- Integrins
- Intestinal Mucosa
- Intestines
- Laminin