Article
CD44v6 increases gastric cancer malignant phenotype by modulating adipose stromal cell-mediated ECM remodeling.
Integrative biology : quantitative biosciences from nano to macro - 1 Mar 2018
Lourenço Bianca N, Springer Nora L, Ferreira Daniel, Oliveira Carla, Granja Pedro L, Fischbach Claudia
Abstract excerpt
CD44, an abundantly expressed adhesion molecule, and its alternative splice variants have been associated with tumorigenesis and metastasis. In the context of gastric cancer (GC), de novo expression of CD44 variant 6 (CD44v6) is found in more than 60% of GCs, but its role in the pathogenesis and progression of this type of cancer remains unclear. Using a combination of media conditioning experiments and...
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