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E-cadherin-defective gastric cancer cells depend on Laminin to survive and invade

5 Aug 2015

Abstract excerpt

Epithelial-cadherin (Ecad) deregulation affects cell-cell adhesion and results in increased invasiveness of distinct human carcinomas. In gastric cancer, loss of Ecad expression is a common event and is associated with disease aggressiveness and poor prognosis. However, the molecular mechanisms underlying the invasive process associated to Ecad dysfunction are far from understood. We hypothesized that...

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PMID: 26246502
DOI: 10.1093/hmg/ddv312

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