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Article

Hic-5 expression is a major indicator of cancer cell morphology, migration, and plasticity in three-dimensional matrices.

Molecular biology of the cell - 15 Jul 2018

Gulvady Anushree C, Dubois Fatemeh, Deakin Nicholas O, Goreczny Gregory J, Turner Christopher E

Abstract excerpt

The focal adhesion proteins Hic-5 and paxillin have been previously identified as key regulators of MDA-MB-231 breast cancer cell migration and morphologic mesenchymal-amoeboid plasticity in three-dimensional (3D) extracellular matrices (ECMs). However, their respective roles in other cancer cell types have not been evaluated. Herein, utilizing 3D cell-derived matrices and fibronectin-coated one-dimensional...

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Identifiers

PMID: 29771639
DOI: 10.1091/mbc.E18-02-0092
PMCID: PMC6080706

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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