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Article

Hyaluronic Acid of Low Molecular Weight Triggers the Invasive "Hummingbird" Phenotype on Gastric Cancer Cells.

Advanced biosystems - 1 Nov 2020

Amorim Sara, Soares da Costa Diana, Pashkuleva Iva, Reis Celso A, Reis Rui L, Pires Ricardo A

Abstract excerpt

The overproduction and deposition of hyaluronic acid (HA) of different sizes in the tumor microenvironment is associated with cancer metastasis. Here, the development of layer-by-layer (LbL) constructs containing HA of different molecular weights (i.e., 5.6, 618, and 1450 kDa) that mimic the HA-rich cancer extracellular matrix is described to study the effect of the HA's size on the behavior of gastric cancer...

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Identifiers

PMID: 33015991
DOI: 10.1002/adbi.202000122

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