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Frequent loss of membranous E-cadherin in gastric cancers: A cross-talk with Wnt in determining the fate of beta-catenin.

Clinical & experimental metastasis - 1 Jan 2005

Cheng Xiao-Xin, Wang Zi-Chuang, Chen Xiao-Yan, Sun Yuan, Kong Qing-You, Liu Jia, Gao Xue, Guan Hong-Wei, Li Hong

Abstract excerpt

The potential correlation of E-cadherin reduction and Wnt2 up-regulation in determining the intracellular distribution of beta-catenin in gastric cancers was investigated by the methods of frozen tissue array-based immunohistochemistry, Western blot and RT-PCR analysis. It was revealed that membranous E-cadherin was reduced frequently in the two major subtypes of gastric cancer (intestinal gastric cancer, i-GC...

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PMID: 16132582
DOI: 10.1007/s10585-005-4578-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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