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Article

Structural basis for the modulation of the neuronal voltage-gated sodium channel NaV1.6 by calmodulin.

Scientific reports - 1 Jan 2013

Reddy Chichili Vishnu Priyanka, Xiao Yucheng, Seetharaman J, Cummins Theodore R, Sivaraman J

Abstract excerpt

The neuronal-voltage gated sodium channel (VGSC), Na(V)1.6, plays an important role in propagating action potentials along myelinated axons. Calmodulin (CaM) is known to modulate the inactivation kinetics of Na(V)1.6 by interacting with its IQ motif. Here we report the crystal structure of apo-CaM:Na(V)1.6IQ motif, along with functional studies. The IQ motif of Na(V)1.6 adopts an α-helical conformation in its...

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Identifiers

PMID: 23942337
DOI: 10.1038/srep02435
PMCID: PMC3743062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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