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Article

The critical role of porcine cytochrome P450 3A46 in the bioactivation of aflatoxin B1.

Biochemical pharmacology - 1 Oct 2018

Jiang Haoran, Wu Jun, Zhang Feiyong, Wen Jikai, Jiang Jun, Deng Yiqun

Abstract excerpt

Aflatoxin B1 (AFB1) is bioactivated by cytochrome P450 (CYP) 3A isoforms in humans to generate the highly reactive epoxide intermediate AFB1-8,9-epoxide (AFBO), causing hepatotoxicity and hepatocarcinoma. Due to the unavoidable contamination in their feed, pigs are more likely to be exposed to AFB1 and indirectly harm human health. Therefore, identifying the porcine CYP3A isoforms involved in AFB1-8,9-epoxidation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 30142320
DOI: 10.1016/j.bcp.2018.08.030

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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