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Article

Molecular insights into the role of a distal F240A mutation that alters CYP1A1 activity towards persistent organic pollutants.

Biochimica et biophysica acta. General subjects - 1 Nov 2017

Navrátilová Veronika, Paloncýová Markéta, Berka Karel, Mise Shintaro, Haga Yuki, Matsumura Chisato, Sakaki Toshiyuki, Inui Hideyuki, Otyepka Michal

Abstract excerpt

BACKGROUND: Cytochromes P450 are major drug-metabolizing enzymes involved in the biotransformation of diverse xenobiotics and endogenous chemicals. Persistent organic pollutants (POPs) are toxic hydrophobic compounds that cause serious environmental problems because of their poor degradability. This calls for rational design of enzymes capable of catalyzing their biotransformation. Cytochrome P450 1A1 isoforms...

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Identifiers

PMID: 28780123
DOI: 10.1016/j.bbagen.2017.08.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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