Interaction of aflatoxin B1 with cytochrome P450 2A5 and its mutants: correlation with metabolic activation and toxicity.

doi:10.1021/tx960078m

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Article

Interaction of aflatoxin B1 with cytochrome P450 2A5 and its mutants: correlation with metabolic activation and toxicity.

Chemical research in toxicology - 1 Jan 1997

Pelkonen P, Lang M A, Negishi M, Wild C P, Juvonen R O

Abstract excerpt

Among members of the mouse cytochrome P450 2A family, P450 2A5 is the best catalyst of aflatoxin B1 (AFB1) oxidation to its 8,9-epoxide (Pelkonen, P., Lang, M., Wild, C. P., Negishi, M., and Juvonen, R. O. (1994) Eur. J. Pharmacol., Environ. Toxicol. Pharmacol. Sect. 292, 67-73). Here we studied...

Topics

Aflatoxin B1
Amino Acids
Aryl Hydrocarbon Hydroxylases
Cytochrome P-450 CYP2A6
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System
Cytochrome P450 Family 2
DNA Adducts
DNA, Fungal
Mixed Function Oxygenases
Mutagens
Mutation
Recombinant Proteins
Saccharomyces cerevisiae
Substrate Specificity

Source

Open in PubMed

Identifiers

PMID: 9074807
DOI: 10.1021/tx960078m

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9074807-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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