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Epoxidation of perillyl alcohol by engineered bacterial cytochrome P450 BM3.

Enzyme and microbial technology - 1 Oct 2024

Park Chan Mi, Cha Gun Su, Jeong Hae Chan, Lee Yu-Jin, Kim Jeong-Hoon, Chung Moon-Soo, Lee Sungbeom, Yun Chul-Ho

Abstract excerpt

Perillyl alcohol (POH) is a secondary metabolite of plants. POH and its derivatives are known to be effective as an anticancer treatment. In this study, oxidative derivatives of POH, which are difficult to synthesize chemically, were synthesized using the engineered bacterial cytochrome P450 BM3 (CYP102A1) as a biocatalyst. The activity of wild-type (WT) CYP102A1 and 29 engineered enzymes toward POH was screened...

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PMID: 39079222
DOI: 10.1016/j.enzmictec.2024.110487

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