Article
Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities.
Nature communications - 25 Mar 2021
Oben Bénedith, Froyen Guy, Maclachlan Kylee H, Leongamornlert Daniel, Abascal Federico, Zheng-Lin Binbin, Yellapantula Venkata, Derkach Andriy, Geerdens Ellen, Diamond Benjamin T, Arijs Ingrid, Maes Brigitte, Vanhees Kimberly, Hultcrantz Malin, Manasanch Elisabet E, Kazandjian Dickran, Lesokhin Alexander, Dogan Ahmet, Zhang Yanming, Mikulasova Aneta, Walker Brian, Morgan Gareth, Campbell Peter J, Landgren Ola, Rummens Jean-Luc, Bolli Niccolò, Maura Francesco
Abstract excerpt
Multiple myeloma (MM) is consistently preceded by precursor conditions recognized clinically as monoclonal gammopathy of undetermined significance (MGUS) or smoldering myeloma (SMM). We interrogate the whole genome sequence (WGS) profile of 18 MGUS and compare them with those from 14 SMMs and 80 MMs. We show that cases with a non-progressing, clinically stable myeloma precursor condition (n = 15) are...
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