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Article

Genomic Profiling to Contextualize the Results of Intervention for Smoldering Multiple Myeloma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2024

Kazandjian Dickran, Diamond Benjamin, Papadimitriou Marios, Hill Elizabeth, Sklavenitis-Pistofidis Romanos, Ziccheddu Bachisio, Blaney Patrick, Chojnacka Monika, Durante Michael, Maclachlan Kylee, Young Ryan, Usmani Saad, Davies Faith, Getz Gad, Ghobrial Irene, Korde Neha, Morgan Gareth, Maura Francesco, Landgren Ola

Abstract excerpt

PURPOSE: Early intervention for high-risk smoldering multiple myeloma (HR-SMM) achieves deep and prolonged responses. It is unclear if beneficial outcomes are due to the treatment of less complex, susceptible disease or inaccuracy in clinical definition of cases entered. EXPERIMENTAL DESIGN: In this study, we interrogated whole-genome and whole-exome sequencing for 54 patients across two HR-SMM interventional...

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Identifiers

PMID: 38652812
DOI: 10.1158/1078-0432.CCR-24-0210
PMCID: PMC11444893

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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