Article
Convergence of evidence from a methylome-wide CpG-SNP association study and GWAS of major depressive disorder.
Translational psychiatry - 22 Aug 2018
Aberg Karolina A, Shabalin Andrey A, Chan Robin F, Zhao Min, Kumar Gaurav, van Grootheest Gerard, Clark Shaunna L, Xie Lin Y, Milaneschi Yuri, Penninx Brenda W J H, van den Oord Edwin J C G
Abstract excerpt
DNA methylation is an epigenetic modification that provides stability and diversity to the cellular phenotype. It is influenced by both genetic sequence variation and environmental factors, and can therefore potentially account for variation of heritable phenotypes and disorders. Therefore, methylome-wide association studies (MWAS) are promising complements to genome-wide association studies (GWAS) of genetic...
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