Article
A methylome-wide mQTL analysis reveals associations of methylation sites with GAD1 and HDAC3 SNPs and a general psychiatric risk score.
Translational psychiatry - 17 Jan 2017
Ciuculete D M, Boström A E, Voisin S, Philipps H, Titova O E, Bandstein M, Nikontovic L, Williams M J, Mwinyi J, Schiöth H B
Abstract excerpt
Genome-wide association studies have identified a number of single-nucleotide polymorphisms (SNPs) that are associated with psychiatric diseases. Increasing body of evidence suggests a complex connection of SNPs and the transcriptional and epigenetic regulation of gene expression, which is poorly understood. In the current study, we investigated the interplay between genetic risk variants, shifts in methylation...
Topics
- Adaptor Proteins, Signal Transducing
- Adolescent
- Adult
- DNA Methylation
- Female
- Formins
- Gene Expression
- Genetic Predisposition to Disease
- Glutamate Decarboxylase
- Histone Deacetylases