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Article

Pazopanib Reduces Phosphorylated Tau Levels and Alters Astrocytes in a Mouse Model of Tauopathy.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Javidnia Monica, Hebron Michaeline L, Xin Yue, Kinney Nikolas G, Moussa Charbel E-H

Abstract excerpt

Hyperphosphorylation and aggregation of tau protein is a critical factor in many neurodegenerative diseases. These diseases are increasing in prevalence, and there are currently no cures. Previous work from our group and others has shown that tyrosine kinase inhibitors (TKIs) can stimulate autophagy, decrease pathological proteins, and improve symptoms in models of neurodegeneration. Here we examined the role of...

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Identifiers

PMID: 28869476
DOI: 10.3233/JAD-170429
PMCID: PMC5757517

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