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Article

The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse.

Neurobiology of disease - 1 Aug 2014

Savolainen Mari H, Richie Christopher T, Harvey Brandon K, Männistö Pekka T, Maguire-Zeiss Kathleen A, Myöhänen Timo T

Abstract excerpt

The misfolding and aggregation of α-synuclein (aSyn) eventually lead to an accumulation of toxic forms that disturb normal neuronal function and result in cell death. aSyn rich inclusions are seen in Parkinson's disease, dementia with Lewy bodies and other synucleinopathies. Prolyl oligopeptidase (PREP) can accelerate the aggregation process of aSyn and the inhibition of PREP leads to a decreased amount of...

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Identifiers

PMID: 24746855
DOI: 10.1016/j.nbd.2014.04.003
PMCID: PMC7254878

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PREP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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