Article

PKB/AKT attenuates Lewy Body-like pathology in primary neurons via Cathepsins B and D

2022-09-26

Abstract excerpt

Motor symptoms of Parkinson’s disease (PD) are caused by the loss of dopamine neurons in the substantia nigra pars compacta. Current PD therapies offer only symptomatic relief, and the research on novel ways to stop or slow down the degeneration of dopamine neurons in PD attracts considerable efforts. A characteristic feature of PD is the abnormal accumulation and spread of misfolded α-synuclein (α-syn) protein le...

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Literature Corpus work: b2e06200-374f-5b78-8eb4-da160dc3950c
DOI: 10.1101/2022.09.23.508066

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