Article
Brr6 plays a role in gene recruitment and transcriptional regulation at the nuclear envelope.
Molecular biology of the cell - 15 Oct 2018
de Bruyn Kops Anne, Burke Jordan E, Guthrie Christine
Abstract excerpt
Correlation between transcriptional regulation and positioning of genes at the nuclear envelope is well established in eukaryotes, but the mechanisms involved are not well understood. We show that brr6-1, a mutant of the essential yeast envelope transmembrane protein Brr6p, impairs normal positioning and expression of the PAB1 and FUR4- GAL1,10,7 loci. Similarly, expression of a dominant negative nucleoplasmic...
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