Brr6 and Brl1 locate to nuclear pore complex assembly sites to promote their biogenesis.

doi:10.1083/jcb.201706024

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Article

Brr6 and Brl1 locate to nuclear pore complex assembly sites to promote their biogenesis.

The Journal of cell biology - 5 Mar 2018

Zhang Wanlu, Neuner Annett, Rüthnick Diana, Sachsenheimer Timo, Lüchtenborg Christian, Brügger Britta, Schiebel Elmar

Abstract excerpt

The paralogous Brr6 and Brl1 are conserved integral membrane proteins of the nuclear envelope (NE) with an unclear role in nuclear pore complex (NPC) biogenesis. Here, we analyzed double-degron mutants of Brr6/Brl1 to understand this function. Depletion of Brr6 and Brl1 caused defects in NPC biogenesis, whereas the already assembled NPCs remained unaffected. This NPC biogenesis defect was not accompanied by a...

Topics

Membrane Lipids
Membrane Proteins
Mutation
Nuclear Pore
Nuclear Pore Complex Proteins
Nuclear Proteins
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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Identifiers

PMID: 29439116
DOI: 10.1083/jcb.201706024
PMCID: PMC5839787

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