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Article

Spatial Proliferation of Epithelial Cells Is Regulated by E-Cadherin Force.

Biophysical journal - 4 Sept 2018

Mohan Abhinav, Schlue Kyle T, Kniffin Alex F, Mayer Carl R, Duke Ashley A, Narayanan Vani, Arsenovic Paul T, Bathula Kranthidhar, Danielsson Brooke E, Dumbali Sandeep P, Maruthamuthu Venkat, Conway Daniel E

Abstract excerpt

Cell proliferation and contact inhibition play a major role in maintaining epithelial cell homeostasis. Prior experiments have shown that externally applied forces, such as stretch, result in increased proliferation in an E-cadherin force-dependent manner. In this study, the spatial regulation of cell proliferation in large epithelial colonies was examined. Surprisingly, cells at the center of the colony still...

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Identifiers

PMID: 30131170
DOI: 10.1016/j.bpj.2018.07.030
PMCID: PMC6127877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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