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Article

E-cadherin engagement stimulates proliferation via Rac1.

The Journal of cell biology - 8 May 2006

Liu Wendy F, Nelson Celeste M, Pirone Dana M, Chen Christopher S

Abstract excerpt

E-cadherin has been linked to the suppression of tumor growth and the inhibition of cell proliferation in culture. We observed that progressively decreasing the seeding density of normal rat kidney-52E (NRK-52E) or MCF-10A epithelial cells from confluence, indeed, released cells from growth arrest. Unexpectedly, a further decrease in seeding density so that cells were isolated from neighboring cells decreased...

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Identifiers

PMID: 16682529
DOI: 10.1083/jcb.200510087
PMCID: PMC2063843

Genes

NRK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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