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Article

Localized elasticity measured in epithelial cells migrating at a wound edge using atomic force microscopy.

American journal of physiology. Lung cellular and molecular physiology - 1 Jul 2008

Wagh Ajay A, Roan Esra, Chapman Kenneth E, Desai Leena P, Rendon David A, Eckstein Eugene C, Waters Christopher M

Abstract excerpt

Restoration of lung homeostasis following injury requires efficient wound healing by the epithelium. The mechanisms of lung epithelial wound healing include cell spreading and migration into the wounded area and later cell proliferation. We hypothesized that mechanical properties of cells vary near the wound edge, and this may provide cues to direct cell migration. To investigate this hypothesis, we measured...

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Identifiers

PMID: 18487359
DOI: 10.1152/ajplung.00475.2007
PMCID: PMC2494778

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AFM

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