Article

Splice switching oligonucleotide mediated gene knockdown in B cells and plasma cells

2020-09-18

Abstract excerpt

<h4>ABSTRACT</h4> The need to identify new therapeutic approaches to the treatment of cancers of the B lymphoid lineage is crucial. Unlike CRISPR/Cas technology, antisense strategies result in transient modifications of gene expression and lack mutagenic effects at the DNA level. Here, we provide evidence for efficient knockdown of c-REL and RELA expression after treatment with splice switching antisense oligonuc...

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Literature Corpus work: d8a7bb3c-fc4d-55a6-86d8-a729540e7b71
DOI: 10.1101/2020.09.18.302984

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