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Article

Rescue of Fmr1KO phenotypes with mGluR5 inhibitors: MRZ-8456 versus AFQ-056.

Neurobiology of disease - 1 Nov 2018

Westmark Pamela R, Dekundy Andrzej, Gravius Andreas, Danysz Wojciech, Westmark Cara J

Abstract excerpt

Metabotropic glutamate receptor 5 (mGluR5) is a drug target for central nervous system disorders such as fragile X syndrome that involve excessive glutamate-induced excitation. We tested the efficacy of a novel negative allosteric modulator of mGluR5 developed by Merz Pharmaceuticals, MRZ-8456, in comparison to MPEP and AFQ-056 (Novartis, a.k.a. mavoglurant) in both in vivo and in vitro assays in a mouse model of...

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PMID: 30125640
DOI: 10.1016/j.nbd.2018.08.008

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APP

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