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Article

Selective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 Feb 2016

Guo Weirui, Molinaro Gemma, Collins Katie A, Hays Seth A, Paylor Richard, Worley Paul F, Szumlinski Karen K, Huber Kimberly M

Abstract excerpt

Altered function of the Gq-coupled, Group 1 metabotropic glutamate receptors, specifically mGlu5, is implicated in multiple mouse models of autism and intellectual disability. mGlu5 dysfunction has been most well characterized in the fragile X syndrome mouse model, the Fmr1 knock-out (KO) mouse, where pharmacological and genetic reduction of mGlu5 reverses many phenotypes. mGlu5 is less associated with its...

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Identifiers

PMID: 26888925
DOI: 10.1523/JNEUROSCI.2921-15.2016
PMCID: PMC4756152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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