Article
The GABAA receptor is an FMRP target with therapeutic potential in fragile X syndrome.
Cell cycle (Georgetown, Tex.) - 1 Jan 2015
Braat Sien, D'Hulst Charlotte, Heulens Inge, De Rubeis Silvia, Mientjes Edwin, Nelson David L, Willemsen Rob, Bagni Claudia, Van Dam Debby, De Deyn Peter P, Kooy R Frank
Abstract excerpt
Previous research indicates that the GABAAergic system is involved in the pathophysiology of the fragile X syndrome, a frequent form of inherited intellectual disability and associated with autism spectrum disorder. However, the molecular mechanism underlying GABAAergic deficits has remained largely unknown. Here, we demonstrate reduced mRNA expression of GABAA receptor subunits in the cortex and cerebellum of...
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