Article

mGluR5 Negative Modulators for Fragile X: Resistance and Persistence

2021-07-03

Abstract excerpt

Fragile X syndrome (FXS) is caused by silencing of the human FMR1 gene and is the leading monogenic cause of intellectual disability and autism. Abundant preclinical data indicated that negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGluR5) might be efficacious in treating FXS in humans. Initial attempts to translate these findings in clinical trials have failed, but these failures pr...

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Literature Corpus work: 16510b15-ed07-53f3-8e30-3a2fe4260ff6
DOI: 10.1101/2021.07.02.450894

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