Article
Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486.
Proceedings of the National Academy of Sciences of the United States of America - 2 Apr 2013
Dolan Bridget M, Duron Sergio G, Campbell David A, Vollrath Benedikt, Shankaranarayana Rao B S, Ko Hui-Yeon, Lin Gregory G, Govindarajan Arvind, Choi Se-Young, Tonegawa Susumu
Abstract excerpt
Fragile X syndrome (FXS) is the most common inherited form of autism and intellectual disability and is caused by the silencing of a single gene, fragile X mental retardation 1 (Fmr1). The Fmr1 KO mouse displays phenotypes similar to symptoms in the human condition--including hyperactivity, repetitive behaviors, and seizures--as well as analogous abnormalities in the density of dendritic spines. Here we take a...
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