Article
Rescue of dendritic spine phenotype in Fmr1 KO mice with the mGluR5 antagonist AFQ056/Mavoglurant.
Psychopharmacology - 1 Mar 2014
Pop Andreea S, Levenga Josien, de Esch Celine E F, Buijsen Ronald A M, Nieuwenhuizen Ingeborg M, Li Tracy, Isaacs Aaron, Gasparini Fabrizio, Oostra Ben A, Willemsen Rob
Abstract excerpt
Fragile X syndrome (FXS) is the leading monogenic cause of intellectual disability and autism. The disease is a result of lack of expression of the fragile X mental retardation protein. Brain tissues of patients with FXS and mice with FMRP deficiency have shown an abnormal dendritic spine phenotype. We investigated the dendritic spine length and density of hippocampal CA1 pyramidal neurons in 2-, 10-, and...
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