Article
Reversal of fragile X phenotypes by manipulation of AβPP/Aβ levels in Fmr1KO mice.
PloS one - 1 Jan 2011
Westmark Cara J, Westmark Pamela R, O'Riordan Kenneth J, Ray Brian C, Hervey Crystal M, Salamat M Shahriar, Abozeid Sara H, Stein Kelsey M, Stodola Levi A, Tranfaglia Michael, Burger Corinna, Berry-Kravis Elizabeth M, Malter James S
Abstract excerpt
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and the leading known genetic cause of autism. Fragile X mental retardation protein (FMRP), which is absent or expressed at substantially reduced levels in FXS, binds to and controls the postsynaptic translation of amyloid β-protein precursor (AβPP) mRNA. Cleavage of AβPP can produce β-amyloid (Aβ), a 39-43 amino acid peptide...
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