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Article

A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells.

Nature biotechnology - 1 Oct 2018

Maoz Ben M, Herland Anna, FitzGerald Edward A, Grevesse Thomas, Vidoudez Charles, Pacheco Alan R, Sheehy Sean P, Park Tae-Eun, Dauth Stephanie, Mannix Robert, Budnik Nikita, Shores Kevin, Cho Alexander, Nawroth Janna C, Segrè Daniel, Budnik Bogdan, Ingber Donald E, Parker Kevin Kit

Abstract excerpt

The neurovascular unit (NVU) regulates metabolic homeostasis as well as drug pharmacokinetics and pharmacodynamics in the central nervous system. Metabolic fluxes and conversions over the NVU rely on interactions between brain microvascular endothelium, perivascular pericytes, astrocytes and neurons, making it difficult to identify the contributions of each cell type. Here we model the human NVU using...

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Identifiers

PMID: 30125269
DOI: 10.1038/nbt.4226
PMCID: PMC9254231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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