Article

SARS-CoV-2 causes human BBB injury and neuroinflammation indirectly in a linked organ chip platform

2021-10-06

Abstract excerpt

<h4>ABSTRACT</h4> COVID-19 is a multi-system disease affecting many organs outside of the lungs, and patients generally develop varying degrees of neurological symptoms. Whereas, the pathogenesis underlying these neurological manifestations remains elusive. Although in vitro models and animal models are widely used in studies of SARS-CoV-2 infection, human organ models that can reflect the pathological alteratio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e6cb3a38-faae-557a-8bd4-ec4a594c94da
DOI: 10.1101/2021.10.05.463205

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2 causes human BBB injury and neuroinflammation indirectly in a linked organ chip platformDOI 10.1101/2021.10.05.463205Read

SARS-CoV-2 infection of human brain microvascular endothelial cells leads to inflammatory activation through NF-κB non-canonical pathway and mitochondrial remodelingSemantic proximity Read

SARS-CoV-2 infection of human brain microvascular endothelial cells leads to inflammatory activation through NF-κB non-canonical pathway and mitochondrial remodelingSemantic proximity Read

Human Brain Microvascular Endothelial Cells Exposure to SARS-CoV-2 Leads to Inflammatory Activation through NF-κB Non-Canonical Pathway and Mitochondrial RemodelingSemantic proximity Read

Recapitulating SARS-CoV-2 Infection in a Human Lung Organoid-on-a-Chip at the Air-Liquid InterfaceSemantic proximity Read

Omics-based analysis of mitochondrial dysfunction and BBB integrity in post-COVID-19 sequelaeSemantic proximity Read

SARS-CoV-2 infects neurons, astrocytes, choroid plexus epithelial cells and pericytes of the human central nervous systemSemantic proximity Read

Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variantsSemantic proximity Read

Quantitative multi-organ proteomics of fatal COVID-19 uncovers tissue-specific effects beyond inflammationSemantic proximity Read

Generation of a Three-dimensional Human Neurovascular Unit Model in a Microfluidic ChipSemantic proximity Read

Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 NeurotropismSemantic proximity Read

Infection of Brain Organoids and 2D Cortical Neurons with SARS-CoV-2 PseudovirusSemantic proximity Read

Preferential uptake of SARS-CoV-2 by pericytes potentiates vascular damage and permeability in an organoid model of the microvasculatureSemantic proximity Read