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Article

Androgen receptor is the key transcriptional mediator of the tumor suppressor SPOP in prostate cancer.

Cancer research - 1 Oct 2014

Geng Chuandong, Rajapakshe Kimal, Shah Shrijal S, Shou John, Eedunuri Vijay Kumar, Foley Christopher, Fiskus Warren, Rajendran Mahitha, Chew Sue Anne, Zimmermann Martin, Bond Richard, He Bin, Coarfa Cristian, Mitsiades Nicholas

Abstract excerpt

Somatic missense mutations in the substrate-binding pocket of the E3 ubiquitin ligase adaptor SPOP are present in up to 15% of human prostate adenocarcinomas, but are rare in other malignancies, suggesting a prostate-specific mechanism of action. SPOP promotes ubiquitination and degradation of several protein substrates, including the androgen receptor (AR) coactivator SRC-3. However, the relative contributions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25274033
DOI: 10.1158/0008-5472.CAN-14-0476
PMCID: PMC4209379

Genes

SPOP
SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Androgen receptor is the key transcriptional mediator of the tumor suppressor SPOP in prostate cancer.PMID 25274033Read ↗

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