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Article

TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression

21 Nov 2018

Abstract excerpt

TRIM24 is an effector substrate of the E3 ubiquitin ligase adaptor SPOP and becomes stabilized in prostate cancer (PCa) with SPOP mutations. However, how TRIM24 protein is regulated in the vast majority of SPOP-wildtype PCa is unknown. Here we report TRIM28 as a critical upstream regulator of TRIM24. TRIM28 protein interacts with TRIM24 to prevent its ubiquitination and degradation by SPOP. Further, TRIM28...

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PMID: 30479348
DOI: 10.1038/s41467-018-07475-5

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