Article

<i>SPOP</i> mutation confers sensitivity to AR-targeted therapy in prostate cancer by reshaping the androgen-driven chromatin landscape

2021-04-21

Abstract excerpt

The normal androgen receptor (AR) cistrome and transcriptional program are fundamentally altered in prostate cancer (PCa). Here, we show that SPOP mutations, an early event in prostate tumorigenesis, reshape the chromatin landscape and AR-directed transcriptional program in normal prostate cells. Induction of SPOP mutation results in DNA accessibility and AR binding patterns found in human PCa. Consistent with d...

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Identifiers and source

Literature Corpus work: 6ffa7314-8bbf-51a2-9cda-eeaa52c21e5d
DOI: 10.1101/2021.04.20.440154

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