Article
Ensemble Properties of Bax Determine Its Function.
Structure (London, England : 1993) - 2 Oct 2018
Robin Adeline Y, Iyer Sweta, Birkinshaw Richard W, Sandow Jarrod, Wardak Ahmad, Luo Cindy S, Shi Melissa, Webb Andrew I, Czabotar Peter E, Kluck Ruth M, Colman Peter M
Abstract excerpt
BAX and BAK are essential mediators of intrinsic apoptosis that permeabilize the mitochondrial outer membrane. BAX activation requires its translocation from cytosol to mitochondria where conformational changes cause its oligomerization. To better understand the critical step of translocation, we examined its blockade by mutation near the C terminus (P168G) or by antibody binding near the N terminus. Similarities...
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