The substitution of Proline 168 favors Bax oligomerization and stimulates its interaction with LUVs and mitochondria.

Abstract excerpt

Bax is a major player in the apoptotic process, being at the core of the mitochondria permeabilization events. In spite of the major recent advances in the knowledge of Bax organization within the membrane, the precise behavior of the C-terminal helix α9 remains elusive, since it was absent from the resolved structure of active Bax. The Proline 168 (P168) residue, located in the short loop between α8 and α9, has...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alanine
• Share to bcl-2-Associated X Protein