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Article

BID-induced structural changes in BAK promote apoptosis.

Nature structural & molecular biology - 1 May 2013

Moldoveanu Tudor, Grace Christy R, Llambi Fabien, Nourse Amanda, Fitzgerald Patrick, Gehring Kalle, Kriwacki Richard W, Green Douglas R

Abstract excerpt

The BCL-2-family protein BAK is responsible for mitochondrial outer-membrane permeabilization (MOMP), which leads to apoptosis. The BCL-2 homology 3 (BH3)-only protein BID activates BAK to perform this function. We report the NMR solution structure of the human BID BH3-BAK complex, which identified the activation site at the canonical BH3-binding groove of BAK. Mutating the BAK BH1 in the groove prevented...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23604079
DOI: 10.1038/nsmb.2563
PMCID: PMC3683554

Genes

BID
BAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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