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Article

Solution Structure of Apoptotic BAX Oligomer: Oligomerization Likely Precedes Membrane Insertion.

Structure (London, England : 1993) - 6 Oct 2015

Sung Tai-Ching, Li Ching-Yu, Lai Yei-Chen, Hung Chien-Lun, Shih Orion, Yeh Yi-Qi, Jeng U-Ser, Chiang Yun-Wei

Abstract excerpt

Proapoptotic BAX protein is largely cytosolic in healthy cells, but it oligomerizes and translocates to mitochondria upon receiving apoptotic stimuli. A long-standing challenge has been the inability to capture any structural information beyond the onset of activation. Here, we present solution structures of an activated BAX oligomer by means of spectroscopic and scattering methods, providing details about the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26299946
DOI: 10.1016/j.str.2015.07.013

Genes

BAX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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