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Article

The role of conformational heterogeneity in regulating the apoptotic activity of BAX protein.

Physical chemistry chemical physics : PCCP - 5 Apr 2017

Kao Te-Yu, Tsai Chia-Jung, Lan Yu-Jing, Chiang Yun-Wei

Abstract excerpt

While activation of BAX is required for initiating mitochondria-mediated apoptosis, the underlying mechanisms remain unsettled. We studied conformations of BAX protein using pressure- and temperature-resolved ESR techniques and obtained the thermodynamic properties of the conformations. We show that inactive BAX is structurally heterogeneous and exists in equilibrium between two major populations of the...

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Identifiers

PMID: 28345702
DOI: 10.1039/c7cp00401j

Genes

BAX

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