Article
To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.
Molecular cell - 9 May 2008
Dewson Grant, Kratina Tobias, Sim Huiyan W, Puthalakath Hamsa, Adams Jerry M, Colman Peter M, Kluck Ruth M
Abstract excerpt
The Bcl-2 relative Bak is thought to drive apoptosis by forming homo-oligomers that permeabilize mitochondria, but how it is activated and oligomerizes is unclear. To clarify these pivotal steps toward apoptosis, we have characterized multiple random loss-of-function Bak mutants and explored the mechanism of Bak conformation change during apoptosis. Single missense mutations located to the alpha helix 2-5 region...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.