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Article

Apigenin Inhibits UVB-Induced Skin Carcinogenesis: The Role of Thrombospondin-1 as an Anti-Inflammatory Factor.

Neoplasia (New York, N.Y.) - 1 Sept 2018

Mirzoeva Salida, Tong Xin, Bridgeman Bryan B, Plebanek Michael P, Volpert Olga V

Abstract excerpt

We have previously demonstrated that apigenin promotes the expression of antiangiogenic protein thrombospondin-1 (TSP1) via a mechanism driven by mRNA-binding protein HuR. Here, we generated a novel mouse model with whole-body THBS-1 gene knockout on SKH-1 genetic background, which allows studies of UVB-induced acute skin damage and carcinogenesis and tests TSP1 involvement in apigenin's anticancer effects....

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Identifiers

PMID: 30118999
DOI: 10.1016/j.neo.2018.07.005
PMCID: PMC6098219

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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