Thrombospondin-2 overexpression in the skin of transgenic mice reduces the susceptibility to chemically induced multistep skin carcinogenesis.

doi:10.1016/j.jdermsci.2014.01.002

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Article

Thrombospondin-2 overexpression in the skin of transgenic mice reduces the susceptibility to chemically induced multistep skin carcinogenesis.

Journal of dermatological science - 1 May 2014

Kunstfeld Rainer, Hawighorst Thomas, Streit Michael, Hong Young-Kwon, Nguyen Lynh, Brown Lawrence F, Detmar Michael

Abstract excerpt

BACKGROUND: We have previously reported stromal upregulation of the endogenous angiogenesis inhibitor thrombospondin-2 (TSP-2) during multistep carcinogenesis, and we found accelerated and enhanced skin angiogenesis and carcinogenesis in TSP-2 deficient mice. GOALS: To investigate whether enhanced levels of TSP-2 might protect from skin cancer development. METHODS: We established transgenic mice with targeted...

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Identifiers

PMID: 24507936
DOI: 10.1016/j.jdermsci.2014.01.002
PMCID: PMC3975683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.