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Article

Immunoregulatory Molecule B7-H1 (CD274) Contributes to Skin Carcinogenesis

6 Jul 2011

Abstract excerpt

B7-H1 (CD274), a member of the B7 family of coinhibitory molecules, is often induced in human tumors and its expression is closely correlated with a poor prognosis or higher malignancy grade. Tumor-associated B7-H1 is implicated in mechanisms of immune escape. Under inflammatory conditions, B7-H1 is also inducible in normal epithelial cells, but little is known about its involvement in the conversion of normal...

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PMID: 21730022
DOI: 10.1158/0008-5472.can-11-0527

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