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Article

IL27 controls skin tumorigenesis via accumulation of ETAR-positive CD11b cells in the pre-malignant skin.

Oncotarget - 22 Nov 2016

Dibra Denada, Mitra Abhisek, Newman Melissa, Xia Xueqing, Keenan Camille, Cutrera Jeffry J, Mathis J Michael, Wang Xiao-Jing, Myers Jeffrey, Li Shulin

Abstract excerpt

Establishment of a permissive pre-malignant niche in concert with mutant stem are key triggers to initiate skin carcinogenesis. An understudied area of research is finding upstream regulators of both these triggers. IL27, a pleiotropic cytokine with both pro- and anti-inflammatory properties, was found to be a key regulator of both. Two step skin carcinogenesis model and K15-KRASG12D mouse model were used to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27738312
DOI: 10.18632/oncotarget.12581
PMCID: PMC5363575

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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